Intern
    Sonderforschungsbereich 630

    Publications

    2015

    A. Reimer, A. Blohm, T. Quack, C. G. Grevelding, V. Kozjak-Pavlovic, T. Rudel, U. Hentschel, U. R. Abdelmohsen; Inhibitory activities of the marine streptomycete-derived compound SF2446A2 against Chlamydia trachomatis and Schistosoma mansoni. J Antibiot (Tokyo) 2015. doi:10.1038/ja.2015.54

    N. C. Nagel, A. Masic, U. Schurigt, W. Boland; Efficient synthesis of (R)-harmonine - the toxic principle of the multicolored Asian lady beetle (Harmonia axyridis). Org Biomol Chem 2015, 13, 5139-5146. doi:10.1039/c5ob00461f

    B. Merget, C. A. Sotriffer; Slow-Onset Inhibition of Mycobacterium tuberculosis InhA: Revealing Molecular Determinants of Residence Time by MD Simulations. PLoS One 2015, 10, e0127009. doi:10.1371/journal.pone.0127009

    M. Kutscher, W. S. Cheow, V. Werner, U. Lorenz, K. Ohlsen, L. Meinel, K. Hadinoto, O. Germershaus; Influence of salt type and ionic strength on self-assembly of dextran sulfate-ciprofloxacin nanoplexes. Int J Pharm 2015, 486, 21-29. doi:10.1016/j.ijpharm.2015.03.022

    P. Kampfer, S. P. Glaeser, H. J. Busse, U. R. Abdelmohsen, U. Hentschel; Rubrobacter aplysinae sp. nov. isolated from the marine sponge Aplysina aerophoba. Int J Syst Evol Microbiol 2015, 65, 1394. doi:10.1099/ijs.0.000171

    J. Glaser, U. Schurigt, B. M. Suzuki, C. R. Caffrey, U. Holzgrabe; Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni. Molecules 2015, 20, 10873-10883. doi:10.3390/molecules200610873

    J. Glaser, M. Schultheis, H. Moll, B. Hazra, U. Holzgrabe; Antileishmanial and cytotoxic compounds from Valeriana wallichii and identification of a novel nepetolactone derivative. Molecules 2015, 20, 5740-5753. doi:10.3390/molecules20045740

    L. R. de Sousa, H. Wu, L. Nebo, J. B. Fernandes, M. F. da Silva, W. Kiefer, T. Schirmeister, P. C. Vieira; Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana. Exp Parasitol 2015, 156, 42-48. doi:10.1016/j.exppara.2015.05.016

    A. Balk, T. Widmer, J. Wiest, H. Bruhn, J. C. Rybak, P. Matthes, K. Muller-Buschbaum, A. Sakalis, T. Luhmann, J. Berghausen, U. Holzgrabe, B. Galli, L. Meinel; Ionic liquid versus prodrug strategy to address formulation challenges. Pharm Res 2015, 32, 2154-2167. doi:10.1007/s11095-014-1607-9

    A. Balk, U. Holzgrabe, L. Meinel; 'Pro et contra' ionic liquid drugs - Challenges and opportunities for pharmaceutical translation. Eur J Pharm Biopharm 2015. doi:10.1016/j.ejpb.2015.05.027

    U. R. Abdelmohsen, T. Grkovic, S. Balasubramanian, M. S. Kamel, R. J. Quinn, U. Hentschel; Elicitation of secondary metabolism in actinomycetes. Biotechnol Adv 2015. doi:10.1016/j.biotechadv.2015.06.003

    S. Schneider, J. Morschhäuser; Induction of Candida albicans drug resistance genes by hybrid zinc cluster transcription factors. Antimicrob Agents Chemother 2015, 59, 558-569. doi:10.1128/AAC.04448-14

    J. Schiebel, A. Chang, B. Merget, G. R. Bommineni, W. Yu, L. A. Spagnuolo, M. V. Baxter, M. Tareilus, P. J. Tonge, C. Kisker, C. A. Sotriffer; An Ordered Water Channel in Staphylococcus aureus FabI: Unraveling the Mechanism of Substrate Recognition and Reduction. Biochemistry 2015, 54, 1943-1955. doi:10.1021/bi5014358

    C. M. Schaefer, R. Lu, N. M. Nesbitt, J. Schiebel, N. S. Sampson, C. Kisker; FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis. Structure 2015, 23, 21-33. doi:10.1016/j.str.2014.10.010

    A. Ponte-Sucre, H. Bruhn, T. Schirmeister, A. Cecil, C. R. Albert, C. Buechold, M. Tischer, S. Schlesinger, T. Goebel, A. Fuss, D. Mathein, B. Merget, C. A. Sotriffer, A. Stich, G. Krohne, M. Engstler, G. Bringmann, U. Holzgrabe; Anti-trypanosomal activities and structural chemical properties of selected compound classes. Parasitol Res 2015, 114, 501-512. doi:10.1007/s00436-014-4210-4

    C. Ott, E. Dorsch, M. Fraunholz, S. Straub, V. Kozjak-Pavlovic; Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS One 2015, 10, e0120213. doi:10.1371/journal.pone.0120213

    M. Faulstich, F. Hagen, E. Avota, V. Kozjak-Pavlovic, A. C. Winkler, Y. Xian, S. Schneider-Schaulies, T. Rudel; Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae. Cell Microbiol 2015, 17, 241-253. doi:10.1111/cmi.12361

    A. Cecil, K. Ohlsen, T. Menzel, P. Francois, J. Schrenzel, A. Fischer, K. Dorries, M. Selle, M. Lalk, J. Hantzschmann, M. Dittrich, C. Liang, J. Bernhardt, T. A. Ölschläger, G. Bringmann, H. Bruhn, M. Unger, A. Ponte-Sucre, L. Lehmann, T. Dandekar; Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells. Int J Med Microbiol 2015, 305, 96-109. doi:10.1016/j.ijmm.2014.11.006

    U. R. Abdelmohsen, C. Cheng, A. Reimer, V. Kozjak-Pavlovic, A. K. Ibrahim, T. Rudel, U. Hentschel, R. Edrada-Ebel, S. A. Ahmed; Antichlamydial Sterol from the Red Sea Sponge Callyspongia aff. implexa. Planta Med 2015. doi:10.1055/s-0035-1545721

    2014

    I. J. Gonzalez-Leal, B. Roger, A. Schwarz, T. Schirmeister, T. Reinheckel, M. B. Lutz, H. Moll; Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection. PLoS Negl Trop Dis 2014, 8, e3194. doi:10.1371/journal.pntd.0003194

    A. Balk, T. Widmer, J. Wiest, H. Bruhn, J. C. Rybak, P. Matthes, K. Muller-Buschbaum, A. Sakalis, T. Luhmann, J. Berghausen, U. Holzgrabe, B. Galli, L. Meinel; Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges. Pharm Res 2014. doi:10.1007/s11095-014-1607-9

    J. Schiebel, A. Chang, S. Shah, Y. Lu, L. Liu, P. Pan, M. W. Hirschbeck, M. Tareilus, S. Eltschkner, W. Yu, J. E. Cummings, S. E. Knudson, G. R. Bommineni, S. G. Walker, R. A. Slayden, C. A. Sotriffer, P. J. Tonge, C. Kisker; Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor. J Biol Chem 2014, 289, 15987-16005. doi:10.1074/jbc.M113.532804

    C. Batram, N. G. Jones, C. J. Janzen, S. M. Markert, M. Engstler; Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei. Elife 2014, 3, e02324. doi:10.7554/eLife.02324

    B. Ramirez-Zavala, S. Mogavero, E. Scholler, C. Sasse, P. D. Rogers, J. Morschhäuser; SAGA/ADA complex subunit Ada2 is required for Cap1-, but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1. Antimicrob Agents Chemother 2014. doi:10.1128/AAC.03065-14

    N. Dunkel, K. Biswas, E. Hiller, K. Fellenberg, S. V. Satheesh, S. Rupp, J. Morschhäuser; Control of morphogenesis, protease secretion and gene expression in Candida albicans by the preferred nitrogen source ammonium. Microbiology 2014. doi:10.1099/mic.0.078238-0

    J. Kamke, C. Rinke, P. Schwientek, K. Mavromatis, N. Ivanova, A. Sczyrba, T. Woyke, U. Hentschel; The Candidate Phylum Poribacteria by Single-Cell Genomics: New Insights into Phylogeny, Cell-Compartmentation, Eukaryote-Like Repeat Proteins, and Other Genomic Features. Plos One 2014, 9. doi:ARTN e87353

    Y. Dashti, T. Grkovic, U. R. Abdelmohsen, U. Hentschel, R. J. Quinn; Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp EG49 and Nocardiopsis sp RV163. Marine Drugs 2014, 12, 3046-3059. doi:Doi 10.3390/Md12053046

    P. Kampfer, S. P. Glaeser, H. J. Busse, U. R. Abdelmohsen, U. Hentschel; Rubrobacter aplysinae sp. nov., isolated from the marine sponge Aplysina aerophoba. Int J Syst Evol Microbiol 2014, 64, 705-709. doi:10.1099/ijs.0.055152-0

    U. R. Abdelmohsen, C. Yang, H. Horn, D. Hajjar, T. Ravasi, U. Hentschel; Actinomycetes from Red Sea sponges: sources for chemical and phylogenetic diversity. Mar Drugs 2014, 12, 2771-2789. doi:10.3390/md12052771

    R. Ettari, A. Pinto, L. Tamborini, I. C. Angelo, S. Grasso, M. Zappala, N. Capodicasa, L. Yzeiraj, E. Gruber, M. N. Aminake, G. Pradel, T. Schirmeister, C. De Micheli, P. Conti; Synthesis and Biological Evaluation of Papain-Family Cathepsin L-Like Cysteine Protease Inhibitors Containing a 1,4-Benzodiazepine Scaffold as Antiprotozoal Agents. ChemMedChem 2014. doi:10.1002/cmdc.201402079

    S. Oli, U. R. Abdelmohsen, U. Hentschel, T. Schirmeister; Identification of plakortide E from the Caribbean sponge Plakortis halichondroides as a trypanocidal protease inhibitor using bioactivity-guided fractionation. Mar Drugs 2014, 12, 2614-2622. doi:10.3390/md12052614

    U. R. Abdelmohsen, C. Cheng, C. Viegelmann, T. Zhang, T. Grkovic, R. J. Quinn, A. Safwat, U. Hentschel, R. Edrada-Ebel; Dereplication strategies for targeted isolation of new anti-trypanosomal actinosporins A and B from a marine sponge associated-Actinokineospora sp. EG49. Mar Drugs accepted.

    W. Lee, B. Engels; The Protonation State of Catalytic Residues in the Resting State of KasA Revisited: Detailed Mechanism for the Activation of KasA by Its OwnSubstrate. Biochemistry 2014, 53, 919-931. doi:10.1021/bi401308j

    J. Glaser, M. Schultheis, S. Hazra, B. Hazra, H. Moll, U. Schurigt, U. Holzgrabe; Antileishmanial lead structures from nature: analysis of structure-activity relationships of a compound library derived from caffeic Acid bornyl ester. Molecules 2014, 19, 1394-1410. doi:10.3390/molecules19021394

    D. W. Begley, D. Fox, 3rd, D. Jenner, C. Juli, P. G. Pierce, J. Abendroth, M. Muruthi, K. Safford, V. Anderson, K. Atkins, S. R. Barnes, S. O. Moen, A. C. Raymond, R. Stacy, P. J. Myler, B. L. Staker, N. J. Harmer, I. H. Norville, U. Holzgrabe, M. Sarkar-Tyson, T. E. Edwards, D. D. Lorimer; A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob Agents Chemother 2014, 58, 1458-1467. doi:10.1128/AAC.01875-13

    M. C. Wilson, T. Mori, C. Ruckert, A. R. Uria, M. J. Helf, K. Takada, C. Gernert, U. A. Steffens, N. Heycke, S. Schmitt, C. Rinke, E. J. Helfrich, A. O. Brachmann, C. Gurgui, T. Wakimoto, M. Kracht, M. Crusemann, U. Hentschel, I. Abe, S. Matsunaga, J. Kalinowski, H. Takeyama, J. Piel; An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 2014, 506, 58-62. doi:10.1038/nature12959

    U. R. Abdelmohsen, K. Bayer, U. Hentschel; Diversity, abundance and natural products of marine sponge-associated actinomycetes. Nat Prod Rep in press doi: 10.1039/C3NP70111E

    T. Hertlein, V. Sturm, U. Lorenz, K. Sumathy, P. Jakob, K. Ohlsen; Bioluminescence and 19F Magnetic Resonance Imaging Visualize the Efficacy of Lysostaphin Alone and in Combination with Oxacillin against Staphylococcus aureus in Murine Thigh and Catheter-Associated Infection Models. Antimicrob Agents Chemother 2014, 58, 1630-1638. doi:10.1128/AAC.01422-13

    2013

    P. Kampfer, S. P. Glaeser, H. J. Busse, U. R. Abdelmohsen, U. Hentschel; Rubrobacter aplysinae sp. nov. isolated from the marine sponge Aplysina aerophoba. Int J Syst Evol Microbiol 2013. doi:10.1099/ijs.0.055152-0

    A. Stich, A. Ponte-Sucre, U. Holzgrabe; Do we need new drugs against human African trypanosomiasis? Lancet Inf Diseases 2013, 13, 733-734. doi:10.1016/S1473-3099(13)70191-9

    M. Lödige, M. D. Lewis, E. S. Paulsen, H. L. Esch, G. Pradel, L. Lehmann, R. Brun, G. Bringmann, A. K. Mueller; A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. Int J Med Microbiol 2013. doi:10.1016/j.ijmm.2013.07.005

    C. J. Ngwa, V. Glockner, U. R. Abdelmohsen, M. Scheuermayer, R. Fischer, U. Hentschel, G. Pradel; 16S rRNA gene-based identification of Elizabethkingia meningoseptica (Flavobacteriales: Flavobacteriaceae) as a dominant midgut bacterium of the Asian malaria vector Anopheles stephensi (Dipteria: Culicidae) with antimicrobial activities. J Med Entomol 2013, 50, 404-414.

    W. Lee, B. Engels; Clarification on the Decarboxylation Mechanism in KasA Based on the Protonation State of Key Residues in the Acyl-Enzyme State. J Phys Chem B 2013, 117, 8095-8104. doi:10.1021/jp403067m

    A. Chang, J. Schiebel, W. Yu, G. R. Bommineni, P. Pan, M. V. Baxter, A. Khanna, C. A. Sotriffer, C. Kisker, P. J. Tonge; Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex. Biochemistry 2013, 52, 4217-4228. doi:10.1021/bi400413c

    K. Ansorg, M. Tafipolsky, B. Engels; Cation-pi Interactions: Accurate Intermolecular Potential from Symmetry-Adapted Perturbation Theory. J Phys Chem B 2013. doi:10.1021/jp403578r

    R. Ettari, L. Tamborini, I. C. Angelo, S. Grasso, T. Schirmeister, L. Lo Presti, C. De Micheli, A. Pinto, P. Conti; Development of rhodesain inhibitors with a 3-bromoisoxazoline warhead. ChemMedChem 2013, 8, 2070-2076. doi:10.1002/cmdc.201300390

    T. Hertlein, V. Sturm, P. Jakob, K. Ohlsen; (19)F Magnetic Resonance Imaging of Perfluorocarbons for the Evaluation of Response to Antibiotic Therapy in a Staphylococcus aureus Infection Model. PLoS One 2013, 8, e64440. doi:10.1371/journal.pone.0064440

    M. Faulstich, J. P. Bottcher, T. F. Meyer, M. Fraunholz, T. Rudel; Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling. PLoS Pathog 2013, 9, e1003373. doi:10.1371/journal.ppat.1003373

    G. Bringmann, K. Thomale, S. Bischof, C. Schneider, M. Schultheis, T. Schwarz, H. Moll, U. Schurigt; A Novel Leishmania major Amastigote Assay in 96-Well Format for Rapid Drug Screening and its Use for the Discovery and Evaluation of a New Class of Leishmanicidal Quinolinium Salts. Antimicrob Agents Chemother 2013. doi:10.1128/AAC.02201-12

    G. Bringmann, B. K. Lombe, C. Steinert, K. N. Ioset, R. Brun, F. Turini, G. Heubl, V. Mudogo; Mbandakamines A and B, Unsymmetrically Coupled Dimeric Naphthylisoquinoline Alkaloids, from a Congolese Ancistrocladus Species. Org Lett 2013, 15, 2590-2593. doi:10.1021/ol4005883

    K. Zeth, V. Kozjak-Pavlovic, M. Faulstich, M. Fraunholz, R. Hurwitz, O. Kepp, T. Rudel; Structure and function of the PorB porin from disseminating Neisseria gonorrhoeae. Biochem J 2013, 449, 631-642. doi:10.1042/BJ20121025

    C. Ott, M. Utech, M. Goetz, T. Rudel, V. Kozjak-Pavlovic; The requirements for the import of neisserial Omp85 into the outer membrane of human mitochondria. Biosci Rep 2013. doi:10.1042/BSR20130007

    B. Merget, D. Zilian, T. Muller, C. A. Sotriffer; MycPermCheck: the Mycobacterium tuberculosis permeability prediction tool for small molecules. Bioinformatics 2013, 29, 62-68. doi:10.1093/bioinformatics/bts641

    N. Dunkel, T. Hertlein, R. Franz, O. Reuss, C. Sasse, T. Schäfer, K. Ohlsen, J. Morschhäuser; Role of different peptide transporters in nutrient acquisition in Candida albicans. Eukaryot Cell 2013. doi:10.1128/EC.00008-13

    G. Bringmann, G. Zhang, T. Büttner, G. Bauckmann, T. Kupfer, H. Braunschweig, R. Brun, V. Mudogo; Jozimine A2: the first dimeric Dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity. Chemistry 2013, 19, 916-923. doi:10.1002/chem.201202755

    2012

    C. M. Topf, J. Schiebel, C. Kisker, U. Holzgrabe; [Old and new anti-mycobacterial drugs. Fatty acid synthesis as a target]. Pharm Unserer Zeit 2012, 41, 64-70.

    M. Tischer, G. Pradel, K. Ohlsen, U. Holzgrabe; Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions? ChemMedChem 2012, 7, 22-31. doi:10.1002/cmdc.201100404

    R. Ettari, N. Micale, G. Grazioso, F. Bova, T. Schirmeister, S. Grasso, M. Zappala; Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors. ChemMedChem 2012, 7, 1594-1600. doi:10.1002/cmdc.201200274

    P. Tabares, B. Degel, N. Schaschke, U. Hentschel, T. Schirmeister; Identification of the protease inhibitor miraziridine A in the Red sea sponge Theonella swinhoei. Pharmacognosy Res 2012, 4, 63-66. doi:10.4103/0974-8490.91047

    J. Schiebel, A. Chang, H. Lu, M. V. Baxter, P. J. Tonge, C. Kisker; Staphylococcus aureus FabI: inhibition, substrate recognition, and potential implications for in vivo essentiality. Structure 2012, 20, 802-813. doi:10.1016/j.str.2012.03.013

    C. Sasse, R. Schillig, A. Reimund, J. Merk, J. Morschhäuser; Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1. Antimicrob Agents Chemother 2012. doi:10.1128/AAC.00264-12

    C. Sasse, N. Dunkel, T. Schafer, S. Schneider, F. Dierolf, K. Ohlsen, J. Morschhäuser; The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans. Mol Microbiol 2012, 86, 539-556. doi:10.1111/j.1365-2958.2012.08210.x

    S. M. Pimentel-Elardo, L. Grozdanov, S. Proksch, U. Hentschel; Diversity of nonribosomal peptide synthetase genes in the microbial metagenomes of marine sponges. Mar Drugs 2012, 10, 1192-1202. doi:10.3390/md10061192

    B. B. Messi, K. Ndjoko-Ioset, B. Hertlein-Amslinger, A. M. Lannang, A. E. Nkengfack, J. L. Wolfender, K. Hostettmann, G. Bringmann; Preussianone, a new flavanone-chromone biflavonoid from Garcinia preussii Engl. Molecules 2012, 17, 6114-6125. doi:10.3390/molecules17056114

    M. W. Hirschbeck, J. Kuper, H. Lu, N. Liu, C. Neckles, S. Shah, S. Wagner, C. A. Sotriffer, P. J. Tonge, C. Kisker; Structure of the Yersinia pestis FabV Enoyl-ACP Reductase and Its Interaction with Two 2-Pyridone Inhibitors. Structure 2012, 20, 89-100. doi:10.1016/j.str.2011.07.019

    G. Hiltensperger, N. G. Jones, S. Niedermeier, A. Stich, M. Kaiser, J. Jung, S. Puhl, A. Damme, H. Braunschweig, L. Meinel, M. Engstler, U. Holzgrabe; Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei. J Med Chem 2012, 55, 2538-2548. doi:10.1021/jm101439s

    L. Glans, W. Hu, C. Jost, C. de Kock, P. J. Smith, M. Haukka, H. Bruhn, U. Schatzschneider, E. Nordlander; Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis. Dalton Trans 2012, 41, 6443-6450. doi:10.1039/c2dt30077j

    V. Ehmke, J. E. Quinsaat, P. Rivera-Fuentes, C. Heindl, C. Freymond, M. Rottmann, R. Brun, T. Schirmeister, F. Diederich; Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors. Org Biomol Chem 2012. doi:10.1039/c2ob00034b

    G. Bringmann, G. Zhang, T. Ölschläger, A. Stich, J. Wu, M. Chatterjee, R. Brun; Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius. Phytochemistry 2012. doi:10.1016/j.phytochem.2012.02.017

    C. Almeida, Y. Hemberger, S. M. Schmitt, S. Bouhired, L. Natesan, S. Kehraus, K. Dimas, M. Gutschow, G. Bringmann, G. M. Konig; Marilines A-C: novel phthalimidines from the sponge-derived fungus Stachylidium sp. Chemistry 2012, 18, 8827-8834. doi:10.1002/chem.201103278

    U. R. Abdelmohsen, M. Szesny, E. M. Othman, T. Schirmeister, S. Grond, H. Stopper, U. Hentschel; Antioxidant and Anti-Protease Activities of Diazepinomicin from the Sponge-Associated Micromonospora Strain RV115. Mar Drugs 2012, 10, 2208-2221. doi:10.3390/md10102208

    2011

    C. Unal, K. F. Schwedhelm, A. Thiele, M. Weiwad, K. Schweimer, F. Frese, G. Fischer, J. Hacker, C. Faber, M. Steinert; Collagen IV-derived peptide binds hydrophobic cavity of Legionella pneumophila Mip and interferes with bacterial epithelial transmigration. Cell Microbiol 2011, 13, 1558-1572. doi:10.1111/j.1462-5822.2011.01641.x

    P. Tabares, S. M. Pimentel-Elardo, T. Schirmeister, T. Hünig, U. Hentschel; Anti-protease and immunomodulatory activities of bacteria associated with Caribbean sponges. Mar Biotechnol (NY) 2011, 13, 883-892. doi:10.1007/s10126-010-9349-0

    V. J. Sturm, T. C. Basse-Lusebrink, T. Kampf, G. Stoll, P. M. Jakob; Improved encoding strategy for CPMG-based Bloch-Siegert B 1+ mapping. Magn Reson Med 2011. doi:10.1002/mrm.23232

    C. A. Sotriffer; Accounting for induced-fit effects in docking: what is possible and what is not? Curr Top Med Chem 2011, 11, 179-191.

    S. Schubert, C. Popp, P. D. Rogers, J. Morschhäuser; Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1. Eukaryot Cell 2011, 10, 1110-1121. doi:10.1128/EC.05100-11

    S. Schubert, K. S. Barker, S. Znaidi, S. Schneider, F. Dierolf, N. Dunkel, M. Aid, G. Boucher, P. D. Rogers, M. Raymond, J. Morschhäuser; Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans. Antimicrob Agents Chemother 2011, 55, 2212-2223. doi:10.1128/AAC.01343-10

    B. Schaefer, C. Kisker, C. A. Sotriffer; Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design. J Comput Aided Mol Des 2011, 25, 1053-1069. doi:10.1007/s10822-011-9483-4

    C. Sasse, R. Schillig, F. Dierolf, M. Weyler, S. Schneider, S. Mogavero, P. D. Rogers, J. Morschhäuser; The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans. PLoS One 2011, 6, e25623. doi:10.1371/journal.pone.0025623

    S. M. Pimentel-Elardo, V. Buback, T. A. Gulder, T. S. Bugni, J. Reppart, G. Bringmann, C. M. Ireland, T. Schirmeister, U. Hentschel; New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities. Mar Drugs 2011, 9, 1682-1697. doi:10.3390/md9101682

    S. Niebling, H. Y. Kuchelmeister, C. Schmuck, S. Schlücker; Quantitative, label-free and site-specific monitoring of molecular recognition: a multivariate resonance Raman approach. Chem Commun (Camb) 2011, 47, 568-570. doi:10.1039/c0cc02052d

    B. Neuhauser, N. Dunkel, S. V. Satheesh, J. Morschhäuser; Role of the Npr1 kinase in ammonium transport and signaling by the ammonium permease Mep2 in Candida albicans. Eukaryot Cell 2011, 10, 332-342. doi:10.1128/EC.00293-10

    S. Mogavero, A. Tavanti, S. Senesi, P. D. Rogers, J. Morschhäuser; Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1. Antimicrob Agents Chemother 2011, 55, 2061-2066. doi:10.1128/AAC.01467-10

    T. M. Menzel, M. Tischer, P. Francois, J. Nickel, J. Schrenzel, H. Bruhn, A. Albrecht, L. Lehmann, U. Holzgrabe, K. Ohlsen; Mode-of-action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus. Antimicrob Agents Chemother 2011, 55, 311-320. doi:10.1128/AAC.00586-10

    L. Liu, T. Bruhn, L. Guo, D. C. Gotz, R. Brun, A. Stich, Y. Che, G. Bringmann; Chloropupukeanolides C-E: cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. Chemistry 2011, 17, 2604-2613. doi:10.1002/chem.201003129

    W. Lee, S. R. Luckner, C. Kisker, P. J. Tonge, B. Engels; Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design. Biochemistry 2011, 50, 5743-5756. doi:10.1021/bi200006t

    S. Langolf, U. Machon, M. Ehlers, W. Sicking, T. Schirmeister, C. Buchhold, C. Gelhaus, P. J. Rosenthal, C. Schmuck; Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks. ChemMedChem 2011, 6, 1581-1586. doi:10.1002/cmdc.201100189

    E. Kugelmann, C. R. Albert, G. Bringmann, U. Holzgrabe; Fenton's oxidation: a tool for the investigation of potential drug metabolites. J Pharm Biomed Anal 2011, 54, 1047-1058. doi:10.1016/j.jpba.2010.12.016

    C. Juli, M. Sippel, J. Jager, A. Thiele, M. Weiwad, K. Schweimer, P. Rosch, M. Steinert, C. A. Sotriffer, U. Holzgrabe; Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein. J Med Chem 2011, 54, 277-283. doi:10.1021/jm101156y

    T. Hertlein, V. Sturm, S. Kircher, T. Basse-Lusebrink, D. Haddad, K. Ohlsen, P. Jakob; Visualization of abscess formation in a murine thigh infection model of Staphylococcus aureus by 19F-magnetic resonance imaging (MRI). PLoS One 2011, 6, e18246. doi:10.1371/journal.pone.0018246

    G. Harms, H. Scherbaum, I. Reiter-Owona, A. Stich, J. Richter; Treatment of imported New World cutaneous leishmaniasis in Germany. Int J Dermatol 2011, 50, 1336-1342. doi:10.1111/j.1365-4632.2011.04987.x

    S. Ghosh, S. Debnath, S. Hazra, A. Hartung, K. Thomale, M. Schultheis, P. Kapkova, U. Schurigt, H. Moll, U. Holzgrabe, B. Hazra; Valeriana wallichii root extracts and fractions with activity against Leishmania spp. Parasitol Res 2011, 108, 861-871. doi:10.1007/s00436-010-2127-0

    M. Gellner, S. Niebling, H. Y. Kuchelmeister, C. Schmuck, S. Schlücker; Plasmonically active micron-sized beads for integrated solid-phase synthesis and label-free SERS analysis. Chem Commun (Camb) 2011, 47, 12762-12764. doi:10.1039/c1cc13562g

    V. Ehmke, C. Heindl, M. Rottmann, C. Freymond, W. B. Schweizer, R. Brun, A. Stich, T. Schirmeister, F. Diederich; Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem 2011, 6, 273-278. doi:10.1002/cmdc.201000449

    N. Dunkel, J. Morschhäuser; Loss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4Delta sap5Delta sap6Delta mutant. Eukaryot Cell 2011, 10, 54-62. doi:10.1128/EC.00281-10

    A. Cecil, C. Rikanovic, K. Ohlsen, C. Liang, J. Bernhardt, T. A. Oelschlaeger, T. Gulder, G. Bringmann, U. Holzgrabe, M. Unger, T. Dandekar; Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells. Genome Biol 2011, 12, R24. doi:10.1186/gb-2011-12-3-r24

    D. Cappel, R. Wahlstrom, R. Brenk, C. A. Sotriffer; Probing the dynamic nature of water molecules and their influences on ligand binding in a model binding site. J Chem Inf Model 2011, 51, 2581-2594. doi:10.1021/ci200052j

    C. Buchold, Y. Hemberger, C. Heindl, A. Welker, B. Degel, T. Pfeuffer, P. Staib, S. Schneider, P. J. Rosenthal, J. Gut, J. Morschhäuser, G. Bringmann, T. Schirmeister; New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors. ChemMedChem 2011, 6, 141-152. doi:10.1002/cmdc.201000370

    G. Bringmann, B. Hertlein-Amslinger, I. Kajahn, M. Dreyer, R. Brun, H. Moll, A. Stich, K. N. Ioset, W. Schmitz, L. H. Ngoc; Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities. Phytochemistry 2011, 72, 89-93. doi:10.1016/j.phytochem.2010.10.006

    G. Bringmann, T. Gulder, T. A. Gulder, M. Breuning; Atroposelective total synthesis of axially chiral biaryl natural products. Chem Rev 2011, 111, 563-639. doi:10.1021/cr100155e

    G. Bergner, C. R. Albert, M. Schiller, G. Bringmann, T. Schirmeister, B. Dietzek, S. Niebling, S. Schlücker, J. Popp; Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy. Analyst 2011, 136, 3686-3693. doi:10.1039/c0an00956c

    2010

    M. Xu, T. Bruhn, B. Hertlein, R. Brun, A. Stich, J. Wu, G. Bringmann; Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius. Chemistry 2010, 16, 4206-4216. doi:10.1002/chem.200903247

    H. Warzecha, D. Ferme, M. Peer, A. Frank, M. Unger; Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4. J Biosci Bioeng 2010, 109, 288-290. doi:10.1016/j.jbiosc.2009.09.001

    T. Waag, C. Gelhaus, J. Rath, A. Stich, M. Leippe, T. Schirmeister; Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett 2010, 20, 5541-5543. doi:10.1016/j.bmcl.2010.07.062

    M. Tischer, L. Sologub, G. Pradel, U. Holzgrabe; The bisnaphthalimides as new active lead compounds against Plasmodium falciparum. Bioorg Med Chem 2010, 18, 2998-3003. doi:10.1016/j.bmc.2010.03.067

    S. Shityakov, T. Dandekar; Lead expansion and virtual screening of Indinavir derivate HIV-1 protease inhibitors using pharmacophoric - shape similarity scoring function. Bioinformation 2010, 4, 295-299.

    U. Schurigt, C. Schad, C. Glowa, U. Baum, K. Thomale, J. K. Schnitzer, M. Schultheis, N. Schaschke, T. Schirmeister, H. Moll; Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles. Antimicrob Agents Chemother 2010, 54, 5028-5041. doi:10.1128/AAC.00327-10

    E. Schunder, P. Adam, F. Higa, K. A. Remer, U. Lorenz, J. Bender, T. Schulz, A. Flieger, M. Steinert, K. Heuner; Phospholipase PlaB is a new virulence factor of Legionella pneumophila. Int J Med Microbiol 2010, 300, 313-323. doi:10.1016/j.ijmm.2010.01.002

    A. Ponte-Sucre, T. Gulder, T. A. Gulder, G. Vollmers, G. Bringmann, H. Moll; Alterations to the structure of Leishmania major induced by N-arylisoquinolines correlate with compound accumulation and disposition. J Med Microbiol 2010, 59, 69-75. doi:10.1099/jmm.0.014241-0

    S. M. Pimentel-Elardo, S. Kozytska, T. S. Bugni, C. M. Ireland, H. Moll, U. Hentschel; Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges. Mar Drugs 2010, 8, 373-380. doi:10.3390/md8020373

    A. Paasche, M. Schiller, T. Schirmeister, B. Engels; Mechanistic study of the reaction of thiol-containing enzymes with alpha,beta-unsaturated carbonyl substrates by computation and chemoassays. ChemMedChem 2010, 5, 869-880. doi:10.1002/cmdc.201000020

    K. Ohlsen, U. Lorenz; Immunotherapeutic strategies to combat staphylococcal infections. Int J Med Microbiol 2010, 300, 402-410. doi:10.1016/j.ijmm.2010.04.015

    B. Nowotny, T. Schneider, G. Pradel, T. Schirmeister, A. Rethwilm, M. Kirschner; Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Antimicrob Agents Chemother 2010, 54, 78-87. doi:10.1128/AAC.00775-09

    S. Niebling, S. K. Srivastava, C. Herrmann, P. R. Wich, C. Schmuck, S. Schlücker; Site-specific pKa determination of the carboxylate-binding subunit in artificial peptide receptors. Chem Commun (Camb) 2010, 46, 2133-2135. doi:10.1039/b926514g

    J. Morschhäuser; Regulation of multidrug resistance in pathogenic fungi. Fungal Genet Biol 2010, 47, 94-106. doi:10.1016/j.fgb.2009.08.002

    C. A. Machutta, G. R. Bommineni, S. R. Luckner, K. Kapilashrami, B. Ruzsicska, C. Simmerling, C. Kisker, P. J. Tonge; Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin. J Biol Chem 2010, 285, 6161-6169. doi:10.1074/jbc.M109.077909

    S. Ludewig, M. Kossner, M. Schiller, K. Baumann, T. Schirmeister; Enzyme kinetics and hit validation in fluorimetric protease assays. Curr Top Med Chem 2010, 10, 368-382.

    S. R. Luckner, N. Liu, C. W. am Ende, P. J. Tonge, C. Kisker; A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis. J Biol Chem 2010, 285, 14330-14337. doi:10.1074/jbc.M109.090373

    C. J. Heilmann, S. Schneider, K. S. Barker, P. D. Rogers, J. Morschhäuser; An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. Antimicrob Agents Chemother 2010, 54, 353-359. doi:10.1128/AAC.01102-09

    G. Fan, Z. Li, S. Shen, Y. Zeng, Y. Yang, M. Xu, T. Bruhn, H. Bruhn, J. Morschhäuser, G. Bringmann, W. Lin; Baculiferins A-O, O-sulfated pyrrole alkaloids with anti-HIV-1 activity, from the Chinese marine sponge Iotrochota baculifera. Bioorg Med Chem 2010, 18, 5466-5474. doi:10.1016/j.bmc.2010.06.052

    R. Ettari, M. Zappala, N. Micale, T. Schirmeister, C. Gelhaus, M. Leippe, A. Evers, S. Grasso; Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain. Eur J Med Chem 2010, 45, 3228-3233. doi:10.1016/j.ejmech.2010.04.003

    M. A. Chlebowicz, K. Nganou, S. Kozytska, J. P. Arends, S. Engelmann, H. Grundmann, K. Ohlsen, J. M. van Dijl, G. Buist; Recombination between ccrC genes in a type V (5C2&5) staphylococcal cassette chromosome mec (SCCmec) of Staphylococcus aureus ST398 leads to conversion from methicillin resistance to methicillin susceptibility in vivo. Antimicrob Agents Chemother 2010, 54, 783-791. doi:10.1128/AAC.00696-09

    G. Bringmann, T. Gulder, B. Hertlein, Y. Hemberger, F. Meyer; Total synthesis of the N,C-coupled naphthylisoquinoline alkaloids ancistrocladinium A and B and related analogues. J Am Chem Soc 2010, 132, 1151-1158. doi:10.1021/ja9097687

    G. Bringmann, S. K. Bischof, S. Muller, T. Gulder, C. Winter, A. Stich, H. Moll, M. Kaiser, R. Brun, J. Dreher, K. Baumann; QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. Eur J Med Chem 2010, 45, 5370-5383. doi:10.1016/j.ejmech.2010.08.062

    A. Breuning, B. Degel, F. Schulz, C. Buchold, M. Stempka, U. Machon, S. Heppner, C. Gelhaus, M. Leippe, M. Leyh, C. Kisker, J. Rath, A. Stich, J. Gut, P. J. Rosenthal, C. Schmuck, T. Schirmeister; Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. J Med Chem 2010, 53, 1951-1963. doi:10.1021/jm900946n

    F. Bova, R. Ettari, N. Micale, C. Carnovale, T. Schirmeister, C. Gelhaus, M. Leippe, S. Grasso, M. Zappala; Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem 2010, 18, 4928-4938. doi:10.1016/j.bmc.2010.06.010

    V. Alptuzun, M. Prinz, V. Horr, J. Scheiber, K. Radacki, A. Fallarero, P. Vuorela, B. Engels, H. Braunschweig, E. Erciyas, U. Holzgrabe; Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases. Bioorg Med Chem 2010, 18, 2049-2059. doi:10.1016/j.bmc.2010.01.002

    U. R. Abdelmohsen, S. M. Pimentel-Elardo, A. Hanora, M. Radwan, S. H. Abou-El-Ela, S. Ahmed, U. Hentschel; Isolation, phylogenetic analysis and anti-infective activity screening of marine sponge-associated actinomycetes. Mar Drugs 2010, 8, 399-412. doi:10.3390/md8030399

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    Recognition, Preparation and Functional Analysis of Agents against Infectious Diseases
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